Nature Communications (Jul 2016)

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination

  • Kathrin Gödde,
  • Olivier Gschwend,
  • Dmytro Puchkov,
  • Carsten K. Pfeffer,
  • Alan Carleton,
  • Thomas J. Jentsch

DOI
https://doi.org/10.1038/ncomms12043
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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Synaptic inhibition in the olfactory bulb (OB) is believed to play a role in odour processing. Here, the authors use a Pcdh21-driven Cre-line to disrupt KCC2 expression in OB mitral cells and find altered synaptic connectivity along with disrupted separation of odour-induced activity patterns.