Nature Communications (Jul 2016)
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
Abstract
Synaptic inhibition in the olfactory bulb (OB) is believed to play a role in odour processing. Here, the authors use a Pcdh21-driven Cre-line to disrupt KCC2 expression in OB mitral cells and find altered synaptic connectivity along with disrupted separation of odour-induced activity patterns.