Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Thomas Barthlott; Adam E. Handel; Hong Ying Teh; Rushika C. Wirasinha; Katrin Hafen; Saulius Žuklys; Benoit Roch; Stuart H. Orkin; Jean-Pierre de Villartay; Stephen R. Daley; Georg A. Holländer

doi:10.1038/s41467-021-24158-w

Nature Communications (Jun 2021)

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Thomas Barthlott,
Adam E. Handel,
Hong Ying Teh,
Rushika C. Wirasinha,
Katrin Hafen,
Saulius Žuklys,
Benoit Roch,
Stuart H. Orkin,
Jean-Pierre de Villartay,
Stephen R. Daley,
Georg A. Holländer

Affiliations

Thomas Barthlott: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Adam E. Handel: Nuffield Department of Clinical Neurosciences, University of Oxford
Hong Ying Teh: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Rushika C. Wirasinha: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
Katrin Hafen: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Saulius Žuklys: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Benoit Roch: Genome Dynamics in the Immune System Laboratory, INSERM UMR 1163, Université de Paris, Imagine Institute
Stuart H. Orkin: Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, and Howard Hughes Medical Institute
Jean-Pierre de Villartay: Genome Dynamics in the Immune System Laboratory, INSERM UMR 1163, Université de Paris, Imagine Institute
Stephen R. Daley: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
Georg A. Holländer: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel

DOI: https://doi.org/10.1038/s41467-021-24158-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TEC subset, and hampers T cell development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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