Open Access Rheumatology: Research and Reviews (Nov 2022)

Anti-Ribosomal-P Antibody Association with Neuropsychiatric Lupus in Sudanese Patients Attending Rheumatology Clinic in Omdurman Military Hospital

  • Taha ZI,
  • Awad Ibrahim IA,
  • Hamza SB,
  • Abdalla YA,
  • Elagib EM,
  • Ali HAM,
  • Joseph S,
  • William J

Journal volume & issue
Vol. Volume 14
pp. 281 – 289

Abstract

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Ziryab Imad Taha,1– 4 Israa Abdelghani Awad Ibrahim,3,4 Salih Boushra Hamza,4,5 Yassin A Abdalla,4,5 Elnour M Elagib,3,4,6 Husam A M Ali,4,7 Sara Joseph,8 Jimmy William4,9 1Medical and Cancer Research Institute (MCRI), Department of Clinical Medicine, Nyala, Sudan; 2University of Bahri, Department of Internal Medicine, Khartoum, Sudan; 3Sudan Medical Specialization Board, Department of Internal Medicine, Khartoum, Sudan; 4Rheumatology Department, Ziryab Research Group, Khartoum, Sudan; 5Omdurman Islamic University, Department of Internal Medicine, Khartoum, Sudan; 6Omdurman Military Hospital, Department of Rheumatology, Omdurman, Sudan; 7Fedail Hospital, Department of Neurology, Khartoum, Sudan; 8University of Medical Sciences and Technology, Department of Pharmacy, Khartoum, Sudan; 9Sligo University Hospital, Department of Haematology, Sligo, IrelandCorrespondence: Jimmy William, Sligo University Hospital, The Mall, Rathquarter, Sligo, F91 H684, Ireland, Tel +353851173213, Email [email protected]: To assess and establish the relationship between neuropsychiatric systemic lupus erythematosus (NPSLE) involvement and serological biomarkers like antiribosomal-P antibodies.Patients and Methods: This is an analytical cross-sectional hospital-based study conducted on patients attending Omdurman Military Hospital from July 2019 to December 2019. A total of 90 patients were enrolled, 30 of whom had NPSLE compared with 60 SLE patients without NPSLE. SLE diagnosis was established based on the revised SLICC criteria (presence of at least 4 criteria) for SLE classification, with neuropsychiatric manifestations defined based on the ACR nomenclature. The immunological examination results have been performed by (ELISA immune-enzymatic method, immunofluorescence, and Western immunoblotting test). SPSS v 21.0 software was utilised for data analysis.Results: NPSLE patients exhibited +ve ANA in 96.7% vs 75% in non-NPSLE (P-value = 0.008), antiribosomal-P antibodies (46.7% vs 20%; P-value = 0.0001), anti-nucleosome antibodies (26.7% vs 5%; P-value = 0.005), and anti-histones antibodies (40% vs 20%; P-value = 0.04). ANA antibodies were significantly associated with neurological manifestations as ANA antibodies were common in epilepsy (n = 9; 91%) and stroke (n = 8; 27.6%) (P-value < 0.001).Conclusion: Neuropsychiatric manifestation of systemic lupus erythematosus exhibits variable clinical manifestations. Neuropsychiatric manifestations of SLE are strongly associated with the anti-ribosomal P antibody presence and can be employed as a powerful diagnostic tool.Keywords: SLE, neuropsychiatric, ANA, anti-ribosomal-P antibodies, anti-histone antibodies

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