Nature Communications (Nov 2021)
An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions
- Julie Routhier,
- Stéphanie Pons,
- Mohamed Lamine Freidja,
- Véronique Dalstein,
- Jérôme Cutrona,
- Antoine Jonquet,
- Nathalie Lalun,
- Jean-Claude Mérol,
- Mark Lathrop,
- Jerry A. Stitzel,
- Gwenola Kervoaze,
- Muriel Pichavant,
- Philippe Gosset,
- Jean-Marie Tournier,
- Philippe Birembaut,
- Valérian Dormoy,
- Uwe Maskos
Affiliations
- Julie Routhier
- Université de Reims Champagne-Ardenne, Inserm
- Stéphanie Pons
- Institut Pasteur, Université de Paris, Integrative Neurobiology of Cholinergic Systems
- Mohamed Lamine Freidja
- Université de Reims Champagne-Ardenne, Inserm
- Véronique Dalstein
- Université de Reims Champagne-Ardenne, Inserm
- Jérôme Cutrona
- Université de Reims Champagne-Ardenne, Inserm
- Antoine Jonquet
- Université de Reims Champagne-Ardenne, Inserm
- Nathalie Lalun
- Université de Reims Champagne-Ardenne, Inserm
- Jean-Claude Mérol
- Université de Reims Champagne-Ardenne, Inserm
- Mark Lathrop
- McGill University Genome Center
- Jerry A. Stitzel
- Institute for Behavioral Genetics, University of Colorado
- Gwenola Kervoaze
- University of Lille, CNRS UMR9017, Inserm U1019, CHU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille
- Muriel Pichavant
- University of Lille, CNRS UMR9017, Inserm U1019, CHU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille
- Philippe Gosset
- University of Lille, CNRS UMR9017, Inserm U1019, CHU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille
- Jean-Marie Tournier
- Université de Reims Champagne-Ardenne, Inserm
- Philippe Birembaut
- Université de Reims Champagne-Ardenne, Inserm
- Valérian Dormoy
- Université de Reims Champagne-Ardenne, Inserm
- Uwe Maskos
- Institut Pasteur, Université de Paris, Integrative Neurobiology of Cholinergic Systems
- DOI
- https://doi.org/10.1038/s41467-021-26637-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Human polymorphisms in nicotinic acetylcholine receptor genes have been linked to both smoking and lung diseases like Chronic Obstructive Pulmonary Disease (COPD) or lung cancer. Here the authors identify a direct role for a human coding polymorphism in COPD-like lesions independent of smoke or nicotine exposure.
