Recent progress in quantitative analysis of self‐assembled peptides
Xiaoyao Cai,
Wei Xu,
Chunhua Ren,
Liping Zhang,
Congrou Zhang,
Jianfeng Liu,
Cuihong Yang
Affiliations
Xiaoyao Cai
Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin P. R. China
Wei Xu
Department of Pathology Characteristic Medical Center of Chinese People's Armed Police Forces Tianjin P. R. China
Chunhua Ren
Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin P. R. China
Liping Zhang
Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin P. R. China
Congrou Zhang
Metabolomics and Analytics Center, Leiden Academic Centre of Drug Research Leiden University Leiden The Netherlands
Jianfeng Liu
Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin P. R. China
Cuihong Yang
Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin P. R. China
Abstract Self‐assembled peptides have been among the important biomaterials due to its excellent biocompatibility and diverse functions. Over the past decades, substantial progress and breakthroughs have been made in designing self‐assembled peptides with multifaceted biomedical applications. The techniques for quantitative analysis, including imaging‐based quantitative techniques, chromatographic technique and computational approach (molecular dynamics simulation), are becoming powerful tools for exploring the structure, properties, biomedical applications, and even supramolecular assembly processes of self‐assembled peptides. However, a comprehensive review concerning these quantitative techniques remains scarce. In this review, recent progress in techniques for quantitative investigation of biostability, cellular uptake, biodistribution, self‐assembly behaviors of self‐assembled peptide etc., are summarized. Specific applications and roles of these techniques are highlighted in detail. Finally, challenges and outlook in this field are concluded. It is believed that this review will provide technical guidance for researchers in the field of peptide‐based materials and pharmaceuticals, and facilitate related research for newcomers in this field.
