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Predictive role of vitamin A serum concentration in psoriatic patients treated with IL-17 inhibitors to prevent skin and systemic fungal infections

Journal of Pharmacological Sciences. 2020;144(1):52-56

 

Journal Homepage

Journal Title: Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)

Publisher: Elsevier

Society/Institution: Japanese Pharmacological Society

LCC Subject Category: Medicine: Therapeutics. Pharmacology

Country of publisher: Japan

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS


Campione Elena (Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Corresponding author. Dermatologic Unit, Department of Systems Medicine University of Rome Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.)

Cosio Terenzio (Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy)

Lanna Caterina (Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy)

Mazzilli Sara (Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy)

Ventura Alessandra (Dermatologic Unit, University of L'Aquila, L'Aquila, Italy)

Dika Emi (Dermatology Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy)

Gaziano Roberta (Microbiology Section, Department of Experimental Medicine and Surgery, University of Rome “Tor Vergata”, Rome, Italy)

Dattola Annunziata (Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy)

Candi Eleonora (Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy)

Bianchi Luca (Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

The use of biological drugs in psoriasis is replacing traditional therapies due to their specific mechanism and limited side effects. However, the use of Interleukin 17 inhibitors and the modification of its cytokine pathway could favor the risk of fungal infections.All-trans retinoic acid is an active metabolite of vitamin A with anti-inflammatory and immunoregulatory properties through its capacity to stimulate both innate and adaptive immunity and to its effects on proliferation, differentiation and apoptosis in a variety of immune cells. Furthermore, it has been recently discovered that All-trans retinoic acid has a direct fungistatic effect against Candida and Aspergillus Fumigatus.On the basis of these new insights, in the current review, we suggest that the evaluation of serum level of All-trans retinoic acid or vitamin A should be considered as a predictive marker for the development of fungal infections among psoriatic patients treated with Interleukin 17 inhibitors.In clinical practice, vitamin A test could be added in the routine hospital diagnostic management for a better selection of psoriatic patients eligible to Interleukin 17 inhibitors.