Rosmarinic Acid Prevents Cisplatin-Induced Liver and Kidney Injury by Inhibiting Inflammatory Responses and Enhancing Total Antioxidant Capacity, Thereby Activating the Nrf2 Signaling Pathway
Yifei Xiang,
Min Ji,
Liqin Wu,
Li Lv,
Qiuling Liang,
Ruihan Deng,
Zhaoyou Deng,
Xia Liu,
Lingyi Ren,
Xin Feng,
Jiakang He
Affiliations
Yifei Xiang
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Min Ji
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Liqin Wu
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Li Lv
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Qiuling Liang
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Ruihan Deng
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Zhaoyou Deng
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Xia Liu
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Lingyi Ren
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Xin Feng
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA
Jiakang He
College of Animal Science and Technology, Guangxi University, Nanning 530005, China
Drug-induced liver and kidney damage is an emergent clinical issue that should be addressed. Rosmarinic acid (RA) has obvious anti-inflammatory and antioxidant effects, so we evaluated the anti-inflammatory and antioxidant effects of RA pretreatment on serum and liver and kidney tissues of cisplatin (CP)-treated mice and explored the possible mechanisms. The results showed that RA pretreatment effectively downregulated the serum, liver, and kidney levels of ALT, AST, BUN, and CRE and the inflammatory factors IL-1β, IL-6, and TNF-α, and simultaneously enhanced the total antioxidant capacity of the liver and kidney. RA pretreatment significantly reduced the levels of MPO, MDA, and NO in liver and kidney tissue, inhibited the mRNA expression of IL-1β, IL-6, and TNF-α in liver and kidney tissue, activated the Nrf2 signaling pathway, and upregulated the mRNA expression of downstream target genes. Our findings show that RA could effectively prevent and alleviate acute liver and kidney injury caused by CP.
