Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives

Abstract

Objectives. To synthesize derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes and evaluate their effect on platelet aggregation and plasma hemostasis.Methods. To determine the qualitative and quantitative composition of the reaction masses, gas chromatography-, chromate mass spectrometry-, and 1H and 13C nuclear magnetic resonance spectrometry methods were used.Results. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were obtained under thermal heating conditions in order to evaluate their effect on platelet aggregation and plasma hemostasis.Conclusions. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were synthesized in high yields. Their effect on platelet aggregation and plasma hemostasis was established.

Keywords

• 5-acyl-1,3-dioxane
• alkylation
• ethers
• isoniazid
• 2,4-dinitrophenyl hydrazine