Research progress of methylation modification in intervertebral disc degeneration

Abstract

Methylation modification is a hot research topic in epigenetics. It plays an important role in cell signal transduction and tissue-specific differentiation by regulating gene expression. Methylation modification also plays a significant role in intervertebral disc degeneration and repair. This article reviews the role and characteristics of methylation modification in the pathogenesis of intervertebral disc degeneration and provides an outlook for future development.

Keywords

• intervertebral disc degeneration
• dna methylation
• histone methylation
• n6-methyladenosine