Nature Communications (Oct 2016)

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

  • Joanna Ratajczak,
  • Magali Joffraud,
  • Samuel A. J. Trammell,
  • Rosa Ras,
  • Núria Canela,
  • Marie Boutant,
  • Sameer S. Kulkarni,
  • Marcelo Rodrigues,
  • Philip Redpath,
  • Marie E. Migaud,
  • Johan Auwerx,
  • Oscar Yanes,
  • Charles Brenner,
  • Carles Cantó

DOI
https://doi.org/10.1038/ncomms13103
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice.