Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging

A. E. Vasdekis; H. Alanazi; A. M. Silverman; C. J. Williams; A. J. Canul; J. B. Cliff; A. C. Dohnalkova; G. Stephanopoulos

doi:10.1038/s41467-019-08717-w

Nature Communications (Feb 2019)

Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging

A. E. Vasdekis,
H. Alanazi,
A. M. Silverman,
C. J. Williams,
A. J. Canul,
J. B. Cliff,
A. C. Dohnalkova,
G. Stephanopoulos

Affiliations

A. E. Vasdekis: Department of Physics, University of Idaho
H. Alanazi: Department of Physics, University of Idaho
A. M. Silverman: Department of Chemical Engineering, Massachusetts Institute of Technology
C. J. Williams: Department of Statistical Science, University of Idaho
A. J. Canul: Department of Physics, University of Idaho
J. B. Cliff: Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory
A. C. Dohnalkova: Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory
G. Stephanopoulos: Department of Chemical Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-019-08717-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

How cellular noise impacts metabolic trade-offs remains unknown. Here, the authors use a quantitative single-cell mass imaging strategy to reveal that cellular noise impacts cellular biomass and triacylglycerol accumulation, as well as protein and fatty-acid recycling under starvation, differently.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal