Frontiers in Cellular and Infection Microbiology (Oct 2022)
Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China
- Dianwu Li,
- Dianwu Li,
- Dianwu Li,
- Dianwu Li,
- Dianwu Li,
- Huaying Liang,
- Huaying Liang,
- Huaying Liang,
- Huaying Liang,
- Huaying Liang,
- Rong Yi,
- Qian Xiao,
- Yiqun Zhu,
- Yiqun Zhu,
- Yiqun Zhu,
- Yiqun Zhu,
- Yiqun Zhu,
- Qinyu Chang,
- Qinyu Chang,
- Qinyu Chang,
- Qinyu Chang,
- Qinyu Chang,
- Lihua Zhou,
- Bin Liu,
- Junjun He,
- Tianxing Liu,
- Zhijun Fan,
- Wei Cheng,
- Weizhong Wang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Pinhua Pan,
- Pinhua Pan,
- Pinhua Pan,
- Pinhua Pan,
- Pinhua Pan
Affiliations
- Dianwu Li
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Dianwu Li
- Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China
- Dianwu Li
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Dianwu Li
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Dianwu Li
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Huaying Liang
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Huaying Liang
- Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China
- Huaying Liang
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Huaying Liang
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Huaying Liang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Rong Yi
- Department of Pulmonary and Critical Care Medicine, Zhuzhou Central Hospital, Zhuzhou, China
- Qian Xiao
- Department of Anaesthesiology, Hunan Provincial People’s Hospital, Changsha, China
- Yiqun Zhu
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Yiqun Zhu
- Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China
- Yiqun Zhu
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Yiqun Zhu
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Yiqun Zhu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Qinyu Chang
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Qinyu Chang
- Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China
- Qinyu Chang
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Qinyu Chang
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Qinyu Chang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Lihua Zhou
- Department of Respiratory Medicine, Changsha Central Hospital, Changsha, China
- Bin Liu
- Department of Emergency, Xiangtan Central Hospital, Xiangtan, China
- Junjun He
- 0Department of General Surgery, Shaoyang Central Hospital, Shaoyang, China
- Tianxing Liu
- 1Department of Orthopaedic Surgery, Yongzhou Central Hospital, Yongzhou, China
- Zhijun Fan
- 2Department of Cardiothoracic Surgery, Liuyang People’s Hospital, Liuyang, China
- Wei Cheng
- 3Department of Respiratory, The Second Xiangya Hospital of Central South University, Changsha, China
- Weizhong Wang
- 4Department of Respiratory, The First Affiliated Hospital of University of South China, Hengyang, China
- Yan Zhang
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Yan Zhang
- Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China
- Yan Zhang
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Yan Zhang
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Yan Zhang
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- Pinhua Pan
- Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China
- Pinhua Pan
- Center of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China
- Pinhua Pan
- Clinical Research Center for Respiratory Diseases in Hunan Province, Changsha, China
- Pinhua Pan
- Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease, Changsha, China
- Pinhua Pan
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China
- DOI
- https://doi.org/10.3389/fcimb.2022.1014530
- Journal volume & issue
-
Vol. 12
Abstract
PurposeLeptospirosis is a zoonotic disease caused by pathogenic spirochetes of the genus Leptospira. However, there is currently no consensual definition or diagnostic criteria for severe and different forms of leptospirosis. Therefore, more insight on clinical manifestations, risk factors, and outcomes of leptospirosis is warranted. The identification of leptospirosis with distinct clinical manifestations and prognosis in our population.MethodsMultiple correspondence analysis and hierarchical classification on principal components were presented to identify different clinical types of leptospirosis. The outcomes were clinical phenotypes, laboratory and imaging findings, and prognosis.ResultsThe 95 enrolled patients had median values of 54.0 years (39.0-65.0) for age, 9.0 (7.0-14.0) for total hospital stay lengths, of whom 86.3% was male and 40.0% was transferred to ICU. Three clinical types were distinguished: mild leptospirosis (n=43, 45.3%) with less organ dysfunction and shorter hospital stays; respiratory leptospirosis (n=28, 29.5%) with hemoptysis, and respiratory and circulatory failure; and hepato-renal leptospirosis (n=24, 25.3%) with worst liver and kidney dysfunction. Total hospital mortality was 15.8% and was associated with dyspnea and high levels of neutrophil counts.ConclusionsThe identification of leptospirosis with distinct clinical manifestations and prognosis in our population may assist clinicians to distinguish leptospirosis-like disease. Moreover, dyspnea and neutrophil count were found to be independent risk factors for severe leptospirosis progression.
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