Pathos (Sep 2011)

Lower intrathecal morphine doses versus conversion doses in cancer pain

  • F. Amato,
  • R. Siciliano,
  • M. Loizzo

Journal volume & issue
Vol. 18, no. 2-3
pp. 11 – 17

Abstract

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Advanced studies in cancer related pain have demonstrated that intrathecal administration of opioids has been much more effective than other drug-administrating routes.The most frequently used drug has been morphine which is the first opioid approved by the US Food and Drug Administration (FDA) for intra-spinal use.Practical conversion rules for different morphine administrating routes were given by Foley et al (1985).Those doses and concentrations are now recommended as a starting doseguideline for the initial phase of treatment.Dosage indicators should be assessed and individualized based on patient response, analgesic requirements and side effects.Therefore, we are herewith presenting findings from a study regardingmorphine doses compared to conversion doses (as per our algorithm) in chronic cancer pain during drug-administration by spinal route.

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