Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections

Darshini Mahadevia; Rinki Saha; Alessia Manganaro; Nao Chuhma; Annette Ziolkowski-Blake; Ashlea A. Morgan; Dani Dumitriu; Stephen Rayport; Mark S. Ansorge

doi:10.1038/s41467-021-27092-z

Nature Communications (Nov 2021)

Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections

Darshini Mahadevia,
Rinki Saha,
Alessia Manganaro,
Nao Chuhma,
Annette Ziolkowski-Blake,
Ashlea A. Morgan,
Dani Dumitriu,
Stephen Rayport,
Mark S. Ansorge

Affiliations

Darshini Mahadevia: Department of Psychiatry, Division of Developmental Neuroscience, Columbia University
Rinki Saha: Department of Psychiatry, Division of Developmental Neuroscience, Columbia University
Alessia Manganaro: Department of Pediatrics, Division for Child and Adolescent Health, Columbia University Irving Medical Center
Nao Chuhma: New York State Psychiatric Institute
Annette Ziolkowski-Blake: New York State Psychiatric Institute
Ashlea A. Morgan: Department of Psychiatry, Division of Developmental Neuroscience, Columbia University
Dani Dumitriu: Department of Psychiatry, Division of Developmental Neuroscience, Columbia University
Stephen Rayport: New York State Psychiatric Institute
Mark S. Ansorge: Department of Psychiatry, Division of Developmental Neuroscience, Columbia University

DOI: https://doi.org/10.1038/s41467-021-27092-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The authors show that terminal activity of dopaminergic neurons selectively projecting from the ventral tegmental area to the lateral septum is sufficient for promoting aggression and necessary for establishing baseline aggression in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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