Cockroach Periplaneta americana Extract as Systemic Anti-inflammatory in Rat of SIRS Model

Abstract

Systemic inflammatory response syndrome is a hyperinflammatory phenomenon mediated by innate immune response due to exposure to infection or non-infection. This study aims to analyze the anti-inflammatory effectiveness of cockroach Periplaneta americana extract through clinical studies in animal models. Induction of SIRS through cecal ligation and puncture. The animal model used 20 10-week-old male Sprague Dawley rats treated with NaCl 0,9%, dexamethasone 0,75 mg, EKP 50 mg, and 100 mg. The therapy was administered orally at 24 and 48 hours after CLP. The results of temperature showed no significant difference between the groups treated with 0,9% NaCl, dexamethasone, and 50 mg EKP (P > 0,05), but significantly different (lower temperature) with the 100 mg EKP group (P 0,05). The total of rats model that experienced SIRS until the end of the study was 66% (NaCl 0,9% and EKP 100 mg), 40% (EKP 50 mg), and 25% (dexamethasone). The study concluted that there was no significant difference result between EKP 50 mg and dexamethasone, so that EKP 50 mg has the potential as a systemic anti-inflammatory in SIRS rats model. cecal ligation and puncture, Cockroach Periplaneta americana, rat, systemic inflammatory response syndrome

Keywords

• cecal ligation and puncture
• cockroach periplaneta americana
• rat