Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation

Eva Malacaria; Giusj Monia Pugliese; Masayoshi Honda; Veronica Marabitti; Francesca Antonella Aiello; Maria Spies; Annapaola Franchitto; Pietro Pichierri

doi:10.1038/s41467-019-09196-9

Nature Communications (Mar 2019)

Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation

Eva Malacaria,
Giusj Monia Pugliese,
Masayoshi Honda,
Veronica Marabitti,
Francesca Antonella Aiello,
Maria Spies,
Annapaola Franchitto,
Pietro Pichierri

Affiliations

Eva Malacaria: Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità
Giusj Monia Pugliese: Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità
Masayoshi Honda: Department of Biochemistry, Carver College of Medicine, University of Iowa
Veronica Marabitti: Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità
Francesca Antonella Aiello: Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità
Maria Spies: Department of Biochemistry, Carver College of Medicine, University of Iowa
Annapaola Franchitto: Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità
Pietro Pichierri: Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità

DOI: https://doi.org/10.1038/s41467-019-09196-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 19

Abstract

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Stabilisation of stalled replication forks prevents excessive fork reversal and genome instability. Here authors reveal a RAD52-dependent replication fork protection mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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