LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation

Julie Brind’Amour; Hisato Kobayashi; Julien Richard Albert; Kenjiro Shirane; Akihiko Sakashita; Asuka Kamio; Aaron Bogutz; Tasuku Koike; Mohammad M. Karimi; Louis Lefebvre; Tomohiro Kono; Matthew C. Lorincz

doi:10.1038/s41467-018-05841-x

Nature Communications (Aug 2018)

LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation

Julie Brind’Amour,
Hisato Kobayashi,
Julien Richard Albert,
Kenjiro Shirane,
Akihiko Sakashita,
Asuka Kamio,
Aaron Bogutz,
Tasuku Koike,
Mohammad M. Karimi,
Louis Lefebvre,
Tomohiro Kono,
Matthew C. Lorincz

Affiliations

Julie Brind’Amour: Department of Medical Genetics, University of British Columbia
Hisato Kobayashi: NODAI Genome Research Center, Tokyo University of Agriculture
Julien Richard Albert: Department of Medical Genetics, University of British Columbia
Kenjiro Shirane: Department of Medical Genetics, University of British Columbia
Akihiko Sakashita: Department of BioScience, Tokyo University of Agriculture
Asuka Kamio: NODAI Genome Research Center, Tokyo University of Agriculture
Aaron Bogutz: Department of Medical Genetics, University of British Columbia
Tasuku Koike: Department of BioScience, Tokyo University of Agriculture
Mohammad M. Karimi: Department of Medical Genetics, University of British Columbia
Louis Lefebvre: Department of Medical Genetics, University of British Columbia
Tomohiro Kono: Department of BioScience, Tokyo University of Agriculture
Matthew C. Lorincz: Department of Medical Genetics, University of British Columbia

DOI: https://doi.org/10.1038/s41467-018-05841-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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