Nature Communications (Aug 2018)

LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation

  • Julie Brind’Amour,
  • Hisato Kobayashi,
  • Julien Richard Albert,
  • Kenjiro Shirane,
  • Akihiko Sakashita,
  • Asuka Kamio,
  • Aaron Bogutz,
  • Tasuku Koike,
  • Mohammad M. Karimi,
  • Louis Lefebvre,
  • Tomohiro Kono,
  • Matthew C. Lorincz

DOI
https://doi.org/10.1038/s41467-018-05841-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.