Nature Communications (Mar 2023)
Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
- Lena Maltan,
- Sarah Weiß,
- Hadil Najjar,
- Melanie Leopold,
- Sonja Lindinger,
- Carmen Höglinger,
- Lorenz Höbarth,
- Matthias Sallinger,
- Herwig Grabmayr,
- Sascha Berlansky,
- Denis Krivic,
- Valentina Hopl,
- Anna Blaimschein,
- Marc Fahrner,
- Irene Frischauf,
- Adéla Tiffner,
- Isabella Derler
Affiliations
- Lena Maltan
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Sarah Weiß
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Hadil Najjar
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Melanie Leopold
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Sonja Lindinger
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Carmen Höglinger
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Lorenz Höbarth
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Matthias Sallinger
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Herwig Grabmayr
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Sascha Berlansky
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Denis Krivic
- Division of Medical Physics and Biophysics, Gottfried Schatz Research Center, Medical University of Graz
- Valentina Hopl
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Anna Blaimschein
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Marc Fahrner
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Irene Frischauf
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Adéla Tiffner
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- Isabella Derler
- Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz
- DOI
- https://doi.org/10.1038/s41467-023-36458-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
The Ca2+ ion channel Orai1 is crucial in immune cells. Here, the authors applied genetic code expansion to transfer light-sensitivity to the Orai1 channel and achieved precise control over its function.
