Lipids in Health and Disease (Dec 2010)

Peroxisome proliferator-activated receptor delta +294T > C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

  • Aung Lynn Htet Htet,
  • Yan Ting-Ting,
  • Hu Xi-Jiang,
  • Li Qing,
  • Cao Xiao-Li,
  • Wu Dong-Feng,
  • Yin Rui-Xing,
  • Miao Lin,
  • Yang De-Zhai,
  • Lin Wei-Xiong

DOI
https://doi.org/10.1186/1476-511X-9-145
Journal volume & issue
Vol. 9, no. 1
p. 145

Abstract

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Abstract Background The association of peroxisome proliferator-activated receptor delta (PPARD) +294T > C polymorphism and serum lipid levels is inconsistent in several previous studies. Bai Ku Yao is an isolated subgroup of the Yao minority in China. The present study was undertaken to detect the association of PPARD +294T > C (rs2016520) polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Methods A total of 609 subjects of Bai Ku Yao and 573 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples. Genotyping of the PPARD +294T > C polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. Results The levels of serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) AI and ApoB were lower in Bai Ku Yao than in Han (P P P P P P Conclusions These results suggest that the association of PPARD +294T > C polymorphism and serum lipid levels is different between the Bai Ku Yao and Han populations. The discrepancy between the two ethnic groups might partly result from different PPARD +294T > C polymorphism or PPARD gene-enviromental interactions.