Nature Communications (Jul 2020)

E2F-dependent transcription determines replication capacity and S phase length

  • Betheney R. Pennycook,
  • Eva Vesela,
  • Silvia Peripolli,
  • Tanya Singh,
  • Alexis R. Barr,
  • Cosetta Bertoli,
  • Robertus A. M. de Bruin

DOI
https://doi.org/10.1038/s41467-020-17146-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.