Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome

Abstract

Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS). The plasma channels of voltage-gated sodium channels (VGSCs), voltage-gated calcium channels (VGCCs) and transient receptor potential channels (TRPs) are involved in IBS gastrointestinal motility and visceral hypersensitivity to varying degrees. They are key pathophysiological and therapeutic targets for regulating gastrointestinal motility and visceral hypersensitivity.

Keywords

• irritable bowel syndrome|pathogenesis|ion channels