[Article title missing]

Abstract

BackgroundHyperglycemic crisis is a critical emergency related to uncontrolled diabetes, and the treatment of which is individualized. Studies have showed that low-dose subcutaneous and insulin infusion with a pump have similar hypoglycemic effects in hyperglycemic crisis, but the former is simpler and more convenient.ObjectiveTo explore hypoglycemic effectsof low-dose subcutaneous versus insulin infusion with a pumpin the treatment of non-comatose hyperglycemic crisis.MethodsOne hundred and fifteen hyperglycemic crisis inpatients〔72 with diabetic ketoacidosis (DKA), and 43 with hyperosmolar hyperglycemic syndrome (HHS) 〕 were selected from Guangzhou Red Cross Hospital from March 2017 to March 2020, and divided into low-dose subcutaneous insulin infusion with a pump (n=58) and low-dose intravenous insulin infusion with a pump (n=57) using random number table, treated with recombinant human insulin, and insulin aspart, respectively. Both groups were treated by a continuous low-dose insulin infusion of 0.10-0.15 U·kg-1·h-1 before meeting the glycemic targets. The speed of blood glucose reduction, time to reach the glycemic targets, average blood glucose and frequency of hypoglycemia were observed in both groups.ResultsThe speed of blood glucose reduction, time to reach the glycemic targets, average blood glucose and frequency of hypoglycemia demonstrated no significant differences in both groups (P>0.05). These four indicators also showed no notable differences in DKA patients in both groups (P>0.05). Furthermore, theyhad no obvious differences in HHS patients in both groups (P>0.05) .ConclusionIn patients with non-comatose hyperglycemic crisis, eitherlow-dose subcutaneous or insulin infusion with a pump could effectively lower the blood glucose, and the former could be used as an alternative for hyperglycemic crisis.

Keywords

• |hyperglycemia crisis|non-comatose|insulin injection methods|blood glucose|intravascular procedures|injections, subcutaneous