Pathological effects of mercury chloride on reproductive system in white rats

Abstract

The present study was undertaken to know the reproductive toxicity of mercury chloride in male and females of white rats. This study was used twelve (6 male and 6 females) white rats of approximately of the same body weight (200-220 g) divided equally in to 3 groups; the first group (T1) was received mercury chloride (1mg/kg B.W intraperitoneally once daily for 30 days). While the second group (T2) was received, mercury chloride (1.5mg/kg B.W intraperitoneally once daily for 30 days).Third group was received only0.2ml of Distilled water considered as control group. At the end of an experiment, the animals were sacrificed and small pieces of (2cm³) were taken from ovary, uterus and testis of all animals to histopathology. Histopathological sections of these organs of (T2) group was showed severe pathological changes characterized by vaculation in epithelial cells of uterus, cystic dilatation of uterine glands with degeneration of epithelial lining of its ,hemorrhage and decrease in number of growing follicles in ovary also there were sever pathological changes in the testes. While (T1) group was showed less pathological changes characterized by hyperplasia of epithelial lining with few and small uterine gland in uterus, presence of large secondary follicles in ovary and there were less pathological changes in testes.