Scientific Reports (Jan 2021)

A study on the bio-applicability of aqueous-dispersed van der Waals 1-D material Nb2Se9 using poloxamer

  • Sudong Chae,
  • Seungbae Oh,
  • Kyung Hwan Choi,
  • Jin Woong Lee,
  • Jiho Jeon,
  • Zhixiang Liu,
  • Cong Wang,
  • Changmo Lim,
  • Xue Dong,
  • Chaeheon Woo,
  • Ghulam Asghar,
  • Liyi Shi,
  • Joohoon Kang,
  • Sung Jae Kim,
  • Si Young Song,
  • Jung Heon Lee,
  • Hak Ki Yu,
  • Jae-Young Choi

DOI
https://doi.org/10.1038/s41598-020-80730-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

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Abstract In this research, dispersion of a new type of one-dimensional inorganic material Nb2Se9, composed of van der Waals bonds, in aqueous solution for bio-application study were studied. To disperse Nb2Se9, which exhibits hydrophobic properties in water, experiments were carried out using a block copolymer (poloxamer) as a dispersant. It was confirmed that PPO, the hydrophobic portion of Poloxamer, was adsorbed onto the surface of Nb2Se9, and PEO, the hydrophilic portion, induced steric hinderance to disperse Nb2Se9 to a size of 10 nm or less. To confirm the adaptability of muscle cells C2C12 to the dispersed Nb2Se9 using poloxamer 188 as dispersant, a MTT assay and a live/dead assay were performed, demonstrating improvement in the viability and proliferation of C2C12 cells.