Nature Communications (Dec 2021)
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α
- Adrien Le Thomas,
- Elena Ferri,
- Scot Marsters,
- Jonathan M. Harnoss,
- David A. Lawrence,
- Iratxe Zuazo-Gaztelu,
- Zora Modrusan,
- Sara Chan,
- Margaret Solon,
- Cécile Chalouni,
- Weihan Li,
- Hartmut Koeppen,
- Joachim Rudolph,
- Weiru Wang,
- Thomas D. Wu,
- Peter Walter,
- Avi Ashkenazi
Affiliations
- Adrien Le Thomas
- Department of Cancer Immunology, Genentech, Inc.
- Elena Ferri
- Department of Structural Biology, Genentech, Inc.
- Scot Marsters
- Department of Cancer Immunology, Genentech, Inc.
- Jonathan M. Harnoss
- Department of Cancer Immunology, Genentech, Inc.
- David A. Lawrence
- Department of Cancer Immunology, Genentech, Inc.
- Iratxe Zuazo-Gaztelu
- Department of Cancer Immunology, Genentech, Inc.
- Zora Modrusan
- Department of Microchemistry, Proteomics and Lipidomics, Genentech, Inc.
- Sara Chan
- Department of Pathology, Genentech, Inc.
- Margaret Solon
- Department of Pathology, Genentech, Inc.
- Cécile Chalouni
- Department of Pathology, Genentech, Inc.
- Weihan Li
- Howard Hughes Medical Institute, University of California
- Hartmut Koeppen
- Department of Pathology, Genentech, Inc.
- Joachim Rudolph
- Department of Discovery Chemistry, Genentech, Inc.
- Weiru Wang
- Department of Structural Biology, Genentech, Inc.
- Thomas D. Wu
- Department of Oncology Bioinformatics Genentech, Inc.
- Peter Walter
- Howard Hughes Medical Institute, University of California
- Avi Ashkenazi
- Department of Cancer Immunology, Genentech, Inc.
- DOI
- https://doi.org/10.1038/s41467-021-27597-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD). Here the authors discover a more promiscuous IRE1 activity dubbed RIDD lacking endomotif (RIDDLE).
