Mediators of Inflammation (Jan 1993)

Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium

  • Yusuf Öztürk,
  • V. Melih Altan,
  • Nuray Yıdızoğlu-Arı,
  • Orhan Altınkurt

DOI
https://doi.org/10.1155/s0962935193000432
Journal volume & issue
Vol. 2, no. 4
pp. 309 – 315

Abstract

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The effects of trifluoperazine and verapamil on bradykinin- and des-Arg9-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events. Verapamil and trifluoperazine inhibited bradykinin induced relaxations and contractions and des-Arg9- bradykinin induced contractions in rat duodenum. Bradykinin induced contractions of ileum were also inhibited by trifluoperazine and. verapamil. Since non-competitive affinity constants of trifluoperazine and verapamil for the relaxant responses to bradykinin in duodenum and for the contractile responses to bradykinin in ileum are different, post-bradykinin receptor events related to calcium may be different in ileum and duodenum. In addition, affinity constants of bradykinin in guinea-pig ileum and rat duodenum are also disparate suggesting the presence of different types of bradykinin B2 receptors in these two organs.