Nature Communications (May 2021)

Polymer-free corticosteroid dimer implants for controlled and sustained drug delivery

  • Kyle Battiston,
  • Ian Parrag,
  • Matthew Statham,
  • Dimitra Louka,
  • Hans Fischer,
  • Gillian Mackey,
  • Adam Daley,
  • Fan Gu,
  • Emily Baldwin,
  • Bingqing Yang,
  • Ben Muirhead,
  • Emily Anne Hicks,
  • Heather Sheardown,
  • Leonid Kalachev,
  • Christopher Crean,
  • Jeffrey Edelman,
  • J. Paul Santerre,
  • Wendy Naimark

DOI
https://doi.org/10.1038/s41467-021-23232-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Polymer-based systems are often considered a necessity for controlled drug delivery, but have well-known limitations. Here, the authors report on drug delivery implants formed solely from corticosteroid dimers, which demonstrate controlled release and overcome many of the challenges of polymer-based systems.