Nature Communications (Nov 2018)
PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
- Qiuhua Yang,
- Jiean Xu,
- Qian Ma,
- Zhiping Liu,
- Varadarajan Sudhahar,
- Yapeng Cao,
- Lina Wang,
- Xianqiu Zeng,
- Yaqi Zhou,
- Min Zhang,
- Yiming Xu,
- Yong Wang,
- Neal L. Weintraub,
- Chunxiang Zhang,
- Tohru Fukai,
- Chaodong Wu,
- Lei Huang,
- Zhen Han,
- Tao Wang,
- David J. Fulton,
- Mei Hong,
- Yuqing Huo
Affiliations
- Qiuhua Yang
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Jiean Xu
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Qian Ma
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Zhiping Liu
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Varadarajan Sudhahar
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Yapeng Cao
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Lina Wang
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Xianqiu Zeng
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Yaqi Zhou
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Min Zhang
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Yiming Xu
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Yong Wang
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Neal L. Weintraub
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Chunxiang Zhang
- Department of Biomedical Engineering, University of Alabama at Birmingham
- Tohru Fukai
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Chaodong Wu
- Department of Nutrition and Food Science, Texas A&M University
- Lei Huang
- Department of Cardiovascular Surgery, Peking University Shenzhen Hospital
- Zhen Han
- Department of Cardiovascular Surgery, Peking University Shenzhen Hospital
- Tao Wang
- Department of Cardiovascular Surgery, Peking University Shenzhen Hospital
- David J. Fulton
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Mei Hong
- Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
- Yuqing Huo
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- DOI
- https://doi.org/10.1038/s41467-018-07132-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Increased glycolysis and inflammatory responses have been observed in endothelial cells exposed to disturbed flow. However, the role of endothelial glycolysis in atherosclerosis is unclear. Here the authors unveil a protective role for glycolysis by showing that endothelial deletion of Prkaa1 accelerates atherosclerosis in hyperlipidemic mice through a reduction of glycolytic metabolism.
