Nature Communications (Apr 2021)
A KRAS-responsive long non-coding RNA controls microRNA processing
- Lei Shi,
- Peter Magee,
- Matteo Fassan,
- Sudhakar Sahoo,
- Hui Sun Leong,
- Dave Lee,
- Robert Sellers,
- Laura Brullé-Soumaré,
- Stefano Cairo,
- Tiziana Monteverde,
- Stefano Volinia,
- Duncan D. Smith,
- Gianpiero Di Leva,
- Francesca Galuppini,
- Athanasios R. Paliouras,
- Kang Zeng,
- Raymond O’Keefe,
- Michela Garofalo
Affiliations
- Lei Shi
- Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester
- Peter Magee
- Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester
- Matteo Fassan
- Department of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua
- Sudhakar Sahoo
- Computational Biology Support, Cancer Research UK Manchester Institute, University of Manchester
- Hui Sun Leong
- Computational Biology Support, Cancer Research UK Manchester Institute, University of Manchester
- Dave Lee
- Computational Biology Support, Cancer Research UK Manchester Institute, University of Manchester
- Robert Sellers
- Computational Biology Support, Cancer Research UK Manchester Institute, University of Manchester
- Laura Brullé-Soumaré
- Xentech, 4 rue Pierre Fontaine
- Stefano Cairo
- Xentech, 4 rue Pierre Fontaine
- Tiziana Monteverde
- Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester
- Stefano Volinia
- Department of Morphology, Surgery and Experimental Medicine, University of Ferrara
- Duncan D. Smith
- Biological Mass Spectrometry Facility, Cancer Research UK Manchester Institute, University of Manchester
- Gianpiero Di Leva
- School of Pharmacy and Bioengineering, Keele University
- Francesca Galuppini
- Department of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua
- Athanasios R. Paliouras
- Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester
- Kang Zeng
- Imaging & Cytometry Facility, Cancer Research UK Manchester Institute, University of Manchester
- Raymond O’Keefe
- Division of Evolution & Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Michela Garofalo
- Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-021-22337-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Wild-type KRAS amplification is known to induce KRAS activation in cancer leading to poor prognostic outcomes. Here the authors identify a KRAS-responsive lncRNA, KIMAT1 that maintains KRAS signalling in lung cancer, suggesting that its targeting may prevent KRAS-driven tumourigenesis.
