Communications Biology (Nov 2022)
Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux
- Dino Luethi,
- Julian Maier,
- Deborah Rudin,
- Dániel Szöllősi,
- Thomas J. F. Angenoorth,
- Stevan Stankovic,
- Matthias Schittmayer,
- Isabella Burger,
- Jae-Won Yang,
- Kathrin Jaentsch,
- Marion Holy,
- Anand Kant Das,
- Mario Brameshuber,
- Gisela Andrea Camacho-Hernandez,
- Andrea Casiraghi,
- Amy Hauck Newman,
- Oliver Kudlacek,
- Ruth Birner-Gruenberger,
- Thomas Stockner,
- Gerhard J. Schütz,
- Harald H. Sitte
Affiliations
- Dino Luethi
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Julian Maier
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Deborah Rudin
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Dániel Szöllősi
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Thomas J. F. Angenoorth
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Stevan Stankovic
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Matthias Schittmayer
- Institute of Chemical Technologies and Analytics, TU Wien
- Isabella Burger
- Institute of Chemical Technologies and Analytics, TU Wien
- Jae-Won Yang
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Kathrin Jaentsch
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Marion Holy
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Anand Kant Das
- Institute of Applied Physics, TU Wien
- Mario Brameshuber
- Institute of Applied Physics, TU Wien
- Gisela Andrea Camacho-Hernandez
- Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse – Intramural Research Program
- Andrea Casiraghi
- Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse – Intramural Research Program
- Amy Hauck Newman
- Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse – Intramural Research Program
- Oliver Kudlacek
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Ruth Birner-Gruenberger
- Institute of Chemical Technologies and Analytics, TU Wien
- Thomas Stockner
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Gerhard J. Schütz
- Institute of Applied Physics, TU Wien
- Harald H. Sitte
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s42003-022-04210-1
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 11
Abstract
Phosphatidylinositol 4,5-bisphosphate (PIP2) directly regulates norepinephrine transporter (NET) dimer stabilization at the plasma membrane. Furthermore, PIP2 interaction with NET affects efflux.
