Frontiers in Cellular and Infection Microbiology (Dec 2023)
Dynamical alterations of brain function and gut microbiome in weight loss
- Jing Zhou,
- Xiaoling Wu,
- Tianyuan Xiang,
- Fei Liu,
- Hui Gao,
- Li Tong,
- Bin Yan,
- Zhonglin Li,
- Chi Zhang,
- Linyuan Wang,
- Lei Ou,
- Zhongxia Li,
- Zhongxia Li,
- Wen Wang,
- Tingting Yang,
- Fengyun Li,
- Huimin Ma,
- Xiaojuan Zhao,
- Na Mi,
- Ziya Yu,
- Canhui Lan,
- Qi Wang,
- Hao Li,
- Liming Wang,
- Xiaoning Wang,
- Yongli Li,
- Qiang Zeng
Affiliations
- Jing Zhou
- Henan Provincial Research Center of Clinical Medicine of Nephropathy, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, China
- Xiaoling Wu
- Department of Nuclear Medicine, Henan Key Laboratory of Chronic Disease Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, China
- Tianyuan Xiang
- Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Fei Liu
- Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
- Hui Gao
- Henan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, China
- Li Tong
- Henan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, China
- Bin Yan
- Henan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, China
- Zhonglin Li
- Department of Radiology, Henan Provincial People’s Hospital, Zhengzhou, Henan, China
- Chi Zhang
- Henan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, China
- Linyuan Wang
- Henan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, China
- Lei Ou
- Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Zhongxia Li
- BYHEALTH Institute of Nutrition & Health, BYHEALTH Co. Ltd, Guangzhou, Guangdong, China
- Zhongxia Li
- Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
- Wen Wang
- Department of Nutrition, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan, Zhengzhou, China
- Tingting Yang
- Department of Nutrition, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan, Zhengzhou, China
- Fengyun Li
- 0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China
- Huimin Ma
- 0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China
- Xiaojuan Zhao
- 0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China
- Na Mi
- 0Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China
- Ziya Yu
- Henan Key Laboratory of Imaging and Intelligent Processing, People’s Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, Henan, China
- Canhui Lan
- 1Beijing Rexinchang Biotechnology Research Institute Co. Ltd, Beijing, China
- Qi Wang
- 2Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, Gansu, China
- Hao Li
- 3Department of Health Management, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China
- Liming Wang
- Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
- Xiaoning Wang
- 4The Institute of Geriatrics, The State Clinic Center for Geriatrics & The State Key Laboratory of Kidney, The People’s Liberation Army (PLA) General Hospital, Beijing, China
- Yongli Li
- 5Department of Health Management, Henan Key Laboratory of Chronic Disease Management, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, Henan, China
- Qiang Zeng
- Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- DOI
- https://doi.org/10.3389/fcimb.2023.1269548
- Journal volume & issue
-
Vol. 13
Abstract
ObjectiveIntermittent energy restriction (IER) is an effective weight loss strategy. However, little is known about the dynamic effects of IER on the brain-gut-microbiome axis.MethodsIn this study, a total of 25 obese individuals successfully lost weight after a 2-month IER intervention. FMRI was used to determine the activity of brain regions. Metagenomic sequencing was performed to identify differentially abundant gut microbes and pathways in from fecal samples.ResultsOur results showed that IER longitudinally reduced the activity of obese-related brain regions at different timepoints, including the inferior frontal orbital gyrus in the cognitive control circuit, the putamen in the emotion and learning circuit, and the anterior cingulate cortex in the sensory circuit. IER longitudinally reduced E. coli abundance across multiple timepoints while elevating the abundance of obesity-related Faecalibacterium prausnitzii, Parabacteroides distasonis, and Bacterokles uniformis. Correlation analysis revealed longitudinally correlations between gut bacteria abundance alterations and brain activity changes.ConclusionsThere was dynamical alteration of BGM axis (the communication of E. coli with specific brain regions) during the weight loss under the IER.
Keywords
- brain-gut-microbiome axis
- weight loss
- functional magnetic resonance imaging
- intermittent energy restriction
- metagenomics
