Novel C‑2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells

Ivo Frydrych; Barbora Choma; Lucie Slavíková; Jan Pokorný; Nikola Jakubcová; Sandra Ludha; Soňa Gurská; Jiří Řehulka; Barbora Lišková; Petr Džubák; Marián Hajdúch; Milan Urban

doi:10.1021/acsomega.4c11479

ACS Omega (Mar 2025)

Novel C‑2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells

Ivo Frydrych,
Barbora Choma,
Lucie Slavíková,
Jan Pokorný,
Nikola Jakubcová,
Sandra Ludha,
Soňa Gurská,
Jiří Řehulka,
Barbora Lišková,
Petr Džubák,
Marián Hajdúch,
Milan Urban

Affiliations

Ivo Frydrych: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
Barbora Choma: Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
Lucie Slavíková: Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
Jan Pokorný: Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
Nikola Jakubcová: Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
Sandra Ludha: Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic
Soňa Gurská: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
Jiří Řehulka: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
Barbora Lišková: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
Petr Džubák: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
Marián Hajdúch: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic
Milan Urban: Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc, Olomouc, Czech Republic

DOI: https://doi.org/10.1021/acsomega.4c11479
Journal volume & issue: Vol. 10, no. 10
pp. 10617 – 10632

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Published in ACS Omega

ISSN: 2470-1343 (Online)
Publisher: American Chemical Society
Country of publisher: United States
LCC subjects: Science: Chemistry
Website: https://pubs.acs.org/journal/acsodf

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