Nature Communications (Feb 2021)
Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice
- Haohao Wu,
- Charles Petitpré,
- Paula Fontanet,
- Anil Sharma,
- Carmelo Bellardita,
- Rolen M. Quadros,
- Paulo R. Jannig,
- Yiqiao Wang,
- J. Alexander Heimel,
- Kylie K. Y. Cheung,
- Simone Wanderoy,
- Yang Xuan,
- Konstantinos Meletis,
- Jorge Ruas,
- Channabasavaiah B. Gurumurthy,
- Ole Kiehn,
- Saida Hadjab,
- François Lallemend
Affiliations
- Haohao Wu
- Department of Neuroscience, Karolinska Institutet
- Charles Petitpré
- Department of Neuroscience, Karolinska Institutet
- Paula Fontanet
- Department of Neuroscience, Karolinska Institutet
- Anil Sharma
- Department of Neuroscience, Karolinska Institutet
- Carmelo Bellardita
- Department of Neuroscience, Karolinska Institutet
- Rolen M. Quadros
- Mouse Genome Engineering Core Facility, Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center
- Paulo R. Jannig
- Department of Physiology and Pharmacology, Karolinska Institutet
- Yiqiao Wang
- Department of Neuroscience, Karolinska Institutet
- J. Alexander Heimel
- Cortical Structure & Function Group, Netherlands Institute for Neuroscience
- Kylie K. Y. Cheung
- Department of Neuroscience, Karolinska Institutet
- Simone Wanderoy
- Department of Neuroscience, Karolinska Institutet
- Yang Xuan
- Department of Neuroscience, Karolinska Institutet
- Konstantinos Meletis
- Department of Neuroscience, Karolinska Institutet
- Jorge Ruas
- Department of Physiology and Pharmacology, Karolinska Institutet
- Channabasavaiah B. Gurumurthy
- Mouse Genome Engineering Core Facility, Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center
- Ole Kiehn
- Department of Neuroscience, Karolinska Institutet
- Saida Hadjab
- Department of Neuroscience, Karolinska Institutet
- François Lallemend
- Department of Neuroscience, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-021-21173-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Molecular diversity of proprioceptive neuron types (Ia, Ib and II PNs) is unclear. Here, the authors characterized the functional organization and development of eight subtypes of PNs in mice. Importantly, Ia subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.
