Deprenyl reduces inflammation during acute SIV infection
K.M. Emanuel,
K. Runner,
Z.D. Brodnik,
B.M. Morsey,
B.G. Lamberty,
H.S. Johnson,
A. Acharya,
S.N. Byrareddy,
R.A. España,
H.S. Fox,
P.J. Gaskill
Affiliations
K.M. Emanuel
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
K. Runner
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
Z.D. Brodnik
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA; Center on Compulsive Behaviors, NIH Intramural Research Program, Baltimore, MD 21224, USA; Integrative Neuroscience Research Branch, Neuronal Networks Section, Baltimore, MD 21224, USA
B.M. Morsey
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
B.G. Lamberty
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
H.S. Johnson
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
A. Acharya
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
S.N. Byrareddy
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
R.A. España
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
H.S. Fox
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
P.J. Gaskill
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA; Corresponding author
Summary: In the era of antiretroviral therapy, inflammation is a central factor in numerous HIV-associated comorbidities, such as cardiovascular disease, cognitive impairment, and neuropsychiatric disorders. This highlights the value of developing therapeutics that both reduce HIV-associated inflammation and treat associated comorbidities. Previous research on monoamine oxidase inhibitors (MAOIs) suggests this class of drugs has anti-inflammatory properties in addition to neuropsychiatric effects. Therefore, we examined the impact of deprenyl, an MAOI, on SIV-associated inflammation during acute SIV infection using the rhesus macaque model of HIV infection. Our results show deprenyl decreased both peripheral and CNS inflammation but had no effect on viral load in either the periphery or CNS. These data show that the MAOI deprenyl may have broad anti-inflammatory effects when given during the acute stage of SIV infection, suggesting more research into the anti-inflammatory effects of this drug could result in a beneficial adjuvant for antiretroviral therapy.
