Stability of Bendamustine Solutions: Influence of Sodium Chloride Concentration, Temperature and Container

Abstract

Bendamustine is used for the treatment of non-Hodgkin lymphoma, chronic lymphocytic leukaemia and myeloma. The stability of bendamustine is highly dependent on temperature and chloride-ion concentration. Limited stability data are available. The objective of this work was to study the stability of the bendamustine reconstituted solution at 2.5 mg/mL and the diluted solution in normal saline and 1.5 % sodium chloride to evaluate a potential increase in stability.

Keywords

• bendamustine
• stability
• hplc dad
• ich