A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma

Abstract

Abstract Pathogenic germline BRCA2 variants may be associated with an increased risk of hypopharyngeal squamous cell carcinoma that is more responsive to chemoradiation and chemotherapeutics targeting defective double‐strand DNA repair.

Keywords

• genetics
• head and neck
• molecular targeted therapies
• oncology
• pharmacology