Nature Communications (Apr 2019)
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
- Manuel A. Ferreira,
- Eric R. Gamazon,
- Fares Al-Ejeh,
- Kristiina Aittomäki,
- Irene L. Andrulis,
- Hoda Anton-Culver,
- Adalgeir Arason,
- Volker Arndt,
- Kristan J. Aronson,
- Banu K. Arun,
- Ella Asseryanis,
- Jacopo Azzollini,
- Judith Balmaña,
- Daniel R. Barnes,
- Daniel Barrowdale,
- Matthias W. Beckmann,
- Sabine Behrens,
- Javier Benitez,
- Marina Bermisheva,
- Katarzyna Białkowska,
- Carl Blomqvist,
- Natalia V. Bogdanova,
- Stig E. Bojesen,
- Manjeet K. Bolla,
- Ake Borg,
- Hiltrud Brauch,
- Hermann Brenner,
- Annegien Broeks,
- Barbara Burwinkel,
- Trinidad Caldés,
- Maria A. Caligo,
- Daniele Campa,
- Ian Campbell,
- Federico Canzian,
- Jonathan Carter,
- Brian D. Carter,
- Jose E. Castelao,
- Jenny Chang-Claude,
- Stephen J. Chanock,
- Hans Christiansen,
- Wendy K. Chung,
- Kathleen B. M. Claes,
- Christine L. Clarke,
- EMBRACE Collaborators,
- GC-HBOC Study Collaborators,
- GEMO Study Collaborators,
- Fergus J. Couch,
- Angela Cox,
- Simon S. Cross,
- Kamila Czene,
- Mary B. Daly,
- Miguel de la Hoya,
- Joe Dennis,
- Peter Devilee,
- Orland Diez,
- Thilo Dörk,
- Alison M. Dunning,
- Miriam Dwek,
- Diana M. Eccles,
- Bent Ejlertsen,
- Carolina Ellberg,
- Christoph Engel,
- Mikael Eriksson,
- Peter A. Fasching,
- Olivia Fletcher,
- Henrik Flyger,
- Eitan Friedman,
- Debra Frost,
- Marike Gabrielson,
- Manuela Gago-Dominguez,
- Patricia A. Ganz,
- Susan M. Gapstur,
- Judy Garber,
- Montserrat García-Closas,
- José A. García-Sáenz,
- Mia M. Gaudet,
- Graham G. Giles,
- Gord Glendon,
- Andrew K. Godwin,
- Mark S. Goldberg,
- David E. Goldgar,
- Anna González-Neira,
- Mark H. Greene,
- Jacek Gronwald,
- Pascal Guénel,
- Christopher A. Haiman,
- Per Hall,
- Ute Hamann,
- Wei He,
- Jane Heyworth,
- Frans B. L. Hogervorst,
- Antoinette Hollestelle,
- Robert N. Hoover,
- John L. Hopper,
- Peter J. Hulick,
- Keith Humphreys,
- Evgeny N. Imyanitov,
- ABCTB Investigators,
- HEBON Investigators,
- BCFR Investigators,
- Claudine Isaacs,
- Milena Jakimovska,
- Anna Jakubowska,
- Paul A. James,
- Ramunas Janavicius,
- Rachel C. Jankowitz,
- Esther M. John,
- Nichola Johnson,
- Vijai Joseph,
- Beth Y. Karlan,
- Elza Khusnutdinova,
- Johanna I. Kiiski,
- Yon-Dschun Ko,
- Michael E. Jones,
- Irene Konstantopoulou,
- Vessela N. Kristensen,
- Yael Laitman,
- Diether Lambrechts,
- Conxi Lazaro,
- Goska Leslie,
- Jenny Lester,
- Fabienne Lesueur,
- Sara Lindström,
- Jirong Long,
- Jennifer T. Loud,
- Jan Lubiński,
- Enes Makalic,
- Arto Mannermaa,
- Mehdi Manoochehri,
- Sara Margolin,
- Tabea Maurer,
- Dimitrios Mavroudis,
- Lesley McGuffog,
- Alfons Meindl,
- Usha Menon,
- Kyriaki Michailidou,
- Austin Miller,
- Marco Montagna,
- Fernando Moreno,
- Lidia Moserle,
- Anna Marie Mulligan,
- Katherine L. Nathanson,
- Susan L. Neuhausen,
- Heli Nevanlinna,
- Ines Nevelsteen,
- Finn C. Nielsen,
- Liene Nikitina-Zake,
- Robert L. Nussbaum,
- Kenneth Offit,
- Edith Olah,
- Olufunmilayo I. Olopade,
- Håkan Olsson,
- Ana Osorio,
- Janos Papp,
- Tjoung-Won Park-Simon,
- Michael T. Parsons,
- Inge Sokilde Pedersen,
- Ana Peixoto,
- Paolo Peterlongo,
- Paul D. P. Pharoah,
- Dijana Plaseska-Karanfilska,
- Bruce Poppe,
- Nadege Presneau,
- Paolo Radice,
- Johanna Rantala,
- Gad Rennert,
- Harvey A. Risch,
- Emmanouil Saloustros,
- Kristin Sanden,
- Elinor J. Sawyer,
- Marjanka K. Schmidt,
- Rita K. Schmutzler,
- Priyanka Sharma,
- Xiao-Ou Shu,
- Jacques Simard,
- Christian F. Singer,
- Penny Soucy,
- Melissa C. Southey,
- John J. Spinelli,
- Amanda B. Spurdle,
- Jennifer Stone,
- Anthony J. Swerdlow,
- William J. Tapper,
- Jack A. Taylor,
- Manuel R. Teixeira,
- Mary Beth Terry,
- Alex Teulé,
- Mads Thomassen,
- Kathrin Thöne,
- Darcy L. Thull,
- Marc Tischkowitz,
- Amanda E. Toland,
- Diana Torres,
- Thérèse Truong,
- Nadine Tung,
- Celine M. Vachon,
- Christi J. van Asperen,
- Ans M. W. van den Ouweland,
- Elizabeth J. van Rensburg,
- Ana Vega,
- Alessandra Viel,
- Qin Wang,
- Barbara Wappenschmidt,
- Jeffrey N. Weitzel,
- Camilla Wendt,
- Robert Winqvist,
- Xiaohong R. Yang,
- Drakoulis Yannoukakos,
- Argyrios Ziogas,
- Peter Kraft,
- Antonis C. Antoniou,
- Wei Zheng,
- Douglas F. Easton,
- Roger L. Milne,
- Jonathan Beesley,
- Georgia Chenevix-Trench
Affiliations
- Manuel A. Ferreira
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Eric R. Gamazon
- Division of Genetic Medicine, Department of Medicine, Vanderbilt University
- Fares Al-Ejeh
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Kristiina Aittomäki
- Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki
- Irene L. Andrulis
- Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Hoda Anton-Culver
- Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine
- Adalgeir Arason
- Department of Pathology, Landspitali University Hospital
- Volker Arndt
- Division of Clinical Epidemiology and Aging Research, C070, German Cancer Research Center (DKFZ)
- Kristan J. Aronson
- Department of Public Health Sciences, and Cancer Research Institute, Queen’s University
- Banu K. Arun
- Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center
- Ella Asseryanis
- Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna
- Jacopo Azzollini
- Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)
- Judith Balmaña
- Oncogenetics Group, Vall dHebron Institute of Oncology (VHIO)
- Daniel R. Barnes
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Daniel Barrowdale
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Matthias W. Beckmann
- Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg
- Sabine Behrens
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Javier Benitez
- Centro de Investigación en Red de Enfermedades Raras (CIBERER)
- Marina Bermisheva
- Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences
- Katarzyna Białkowska
- Department of Genetics and Pathology, Pomeranian Medical University
- Carl Blomqvist
- Department of Oncology, Helsinki University Hospital, University of Helsinki
- Natalia V. Bogdanova
- Department of Radiation Oncology, Hannover Medical School
- Stig E. Bojesen
- Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Manjeet K. Bolla
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Ake Borg
- Department of Oncology, Lund University and Skåne University Hospital
- Hiltrud Brauch
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, C070, German Cancer Research Center (DKFZ)
- Annegien Broeks
- Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Barbara Burwinkel
- Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ)
- Trinidad Caldés
- Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
- Maria A. Caligo
- Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa
- Daniele Campa
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Ian Campbell
- Research Department, Peter MacCallum Cancer Center
- Federico Canzian
- Genomic Epidemiology Group, German Cancer Research Center (DKFZ)
- Jonathan Carter
- Department of Gynaecological Oncology, Chris O’Brien Lifehouse and The University of Sydney
- Brian D. Carter
- Behavioral and Epidemiology Research Group, American Cancer Society
- Jose E. Castelao
- Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- Hans Christiansen
- Department of Radiation Oncology, Hannover Medical School
- Wendy K. Chung
- Departments of Pediatrics and Medicine, Columbia University
- Kathleen B. M. Claes
- Centre for Medical Genetics, Ghent University
- Christine L. Clarke
- Westmead Institute for Medical Research, University of Sydney
- EMBRACE Collaborators
- GC-HBOC Study Collaborators
- GEMO Study Collaborators
- Fergus J. Couch
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Angela Cox
- Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield
- Simon S. Cross
- Academic Unit of Pathology, Department of Neuroscience, University of Sheffield
- Kamila Czene
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Mary B. Daly
- Department of Clinical Genetics, Fox Chase Cancer Center
- Miguel de la Hoya
- Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
- Joe Dennis
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Peter Devilee
- Department of Pathology, Leiden University Medical Center
- Orland Diez
- Oncogenetics Group, Vall dHebron Institute of Oncology (VHIO)
- Thilo Dörk
- Gynaecology Research Unit, Hannover Medical School
- Alison M. Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Miriam Dwek
- Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster
- Diana M. Eccles
- Faculty of Medicine, University of Southampton
- Bent Ejlertsen
- Department of Oncology, Rigshospitalet, Copenhagen University Hospital
- Carolina Ellberg
- Department of Cancer Epidemiology, Clinical Sciences, Lund University
- Christoph Engel
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Mikael Eriksson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Peter A. Fasching
- Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg
- Olivia Fletcher
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Henrik Flyger
- Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital
- Eitan Friedman
- The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center
- Debra Frost
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Marike Gabrielson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Manuela Gago-Dominguez
- Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS
- Patricia A. Ganz
- Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA
- Susan M. Gapstur
- Behavioral and Epidemiology Research Group, American Cancer Society
- Judy Garber
- Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute
- Montserrat García-Closas
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- José A. García-Sáenz
- Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC)
- Mia M. Gaudet
- Behavioral and Epidemiology Research Group, American Cancer Society
- Graham G. Giles
- Cancer Epidemiology & Intelligence Division, Cancer Council Victoria
- Gord Glendon
- Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Andrew K. Godwin
- Department of Pathology and Laboratory Medicine, Kansas University Medical Center
- Mark S. Goldberg
- Department of Medicine, McGill University
- David E. Goldgar
- Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine
- Anna González-Neira
- Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)
- Mark H. Greene
- Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jacek Gronwald
- Department of Genetics and Pathology, Pomeranian Medical University
- Pascal Guénel
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Per Hall
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Ute Hamann
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Wei He
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Jane Heyworth
- School of Population and Global Health, The University of Western Australia
- Frans B. L. Hogervorst
- Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital
- Antoinette Hollestelle
- Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute
- Robert N. Hoover
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- John L. Hopper
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Peter J. Hulick
- Center for Medical Genetics, NorthShore University HealthSystem
- Keith Humphreys
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Evgeny N. Imyanitov
- N.N. Petrov Institute of Oncology. St.
- ABCTB Investigators
- HEBON Investigators
- BCFR Investigators
- Claudine Isaacs
- Lombardi Comprehensive Cancer Center, Georgetown University
- Milena Jakimovska
- Research Centre for Genetic Engineering and Biotechnology ‘Georgi D. Efremov’, Macedonian Academy of Sciences and Arts
- Anna Jakubowska
- Department of Genetics and Pathology, Pomeranian Medical University
- Paul A. James
- Sir Peter MacCallum Department of Oncology, The University of Melbourne
- Ramunas Janavicius
- Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics
- Rachel C. Jankowitz
- Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine
- Esther M. John
- Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine
- Nichola Johnson
- The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research
- Vijai Joseph
- Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
- Beth Y. Karlan
- David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles
- Elza Khusnutdinova
- Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences
- Johanna I. Kiiski
- Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki
- Yon-Dschun Ko
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus
- Michael E. Jones
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Irene Konstantopoulou
- Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos’
- Vessela N. Kristensen
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet
- Yael Laitman
- The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center
- Diether Lambrechts
- VIB Center for Cancer Biology, VIB
- Conxi Lazaro
- Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC
- Goska Leslie
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Jenny Lester
- David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles
- Fabienne Lesueur
- Genetic Epidemiology of Cancer team, Inserm U900
- Sara Lindström
- Department of Epidemiology, University of Washington School of Public Health
- Jirong Long
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Jennifer T. Loud
- Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jan Lubiński
- Department of Genetics and Pathology, Pomeranian Medical University
- Enes Makalic
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Arto Mannermaa
- Translational Cancer Research Area, University of Eastern Finland
- Mehdi Manoochehri
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Sara Margolin
- Department of Oncology, Södersjukhuset
- Tabea Maurer
- Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf
- Dimitrios Mavroudis
- Department of Medical Oncology, University Hospital of Heraklion
- Lesley McGuffog
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Alfons Meindl
- Department of Gynecology and Obstetrics, University of Munich, Campus Großhadern
- Usha Menon
- MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London
- Kyriaki Michailidou
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Austin Miller
- NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute
- Marco Montagna
- Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS
- Fernando Moreno
- Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC)
- Lidia Moserle
- Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS
- Anna Marie Mulligan
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Katherine L. Nathanson
- Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania
- Susan L. Neuhausen
- Department of Population Sciences, Beckman Research Institute of City of Hope
- Heli Nevanlinna
- Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki
- Ines Nevelsteen
- Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven
- Finn C. Nielsen
- Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital
- Liene Nikitina-Zake
- Latvian Biomedical Research and Study Centre
- Robert L. Nussbaum
- Cancer Genetics and Prevention Program, University of California San Francisco
- Kenneth Offit
- Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
- Edith Olah
- Department of Molecular Genetics, National Institute of Oncology
- Olufunmilayo I. Olopade
- Center for Clinical Cancer Genetics, The University of Chicago
- Håkan Olsson
- Department of Cancer Epidemiology, Clinical Sciences, Lund University
- Ana Osorio
- Centro de Investigación en Red de Enfermedades Raras (CIBERER)
- Janos Papp
- Department of Molecular Genetics, National Institute of Oncology
- Tjoung-Won Park-Simon
- Gynaecology Research Unit, Hannover Medical School
- Michael T. Parsons
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Inge Sokilde Pedersen
- Molecular Diagnostics, Aalborg University Hospital
- Ana Peixoto
- Department of Genetics, Portuguese Oncology Institute
- Paolo Peterlongo
- Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology
- Paul D. P. Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Dijana Plaseska-Karanfilska
- Research Centre for Genetic Engineering and Biotechnology ‘Georgi D. Efremov’, Macedonian Academy of Sciences and Arts
- Bruce Poppe
- Centre for Medical Genetics, Ghent University
- Nadege Presneau
- Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster
- Paolo Radice
- Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT)
- Johanna Rantala
- Clinical Genetics, Karolinska Institutet
- Gad Rennert
- Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine
- Harvey A. Risch
- Chronic Disease Epidemiology, Yale School of Public Health
- Emmanouil Saloustros
- Department of Oncology, University Hospital of Larissa
- Kristin Sanden
- City of Hope Clinical Cancer Genetics Community Research Network
- Elinor J. Sawyer
- Research Oncology, Guy’s Hospital, King’s College London
- Marjanka K. Schmidt
- Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Rita K. Schmutzler
- Center for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Priyanka Sharma
- Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center
- Xiao-Ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Jacques Simard
- Genomics Center, Centre Hospitalier Universitaire de Québec – Université Laval, Research Center
- Christian F. Singer
- Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna
- Penny Soucy
- Genomics Center, Centre Hospitalier Universitaire de Québec – Université Laval, Research Center
- Melissa C. Southey
- Precision Medicine, School of Clinical Sciences at Monash Health, Monash University
- John J. Spinelli
- Population Oncology, BC Cancer
- Amanda B. Spurdle
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Jennifer Stone
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Anthony J. Swerdlow
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- William J. Tapper
- Faculty of Medicine, University of Southampton
- Jack A. Taylor
- Epidemiology Branch, National Institute of Environmental Health Sciences, NIH
- Manuel R. Teixeira
- Department of Genetics, Portuguese Oncology Institute
- Mary Beth Terry
- Department of Epidemiology, Mailman School of Public Health, Columbia University
- Alex Teulé
- Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC
- Mads Thomassen
- Department of Clinical Genetics, Odense University Hospital
- Kathrin Thöne
- Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf
- Darcy L. Thull
- Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine
- Marc Tischkowitz
- Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University
- Amanda E. Toland
- Department of Cancer Biology and Genetics, The Ohio State University
- Diana Torres
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Thérèse Truong
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay
- Nadine Tung
- Department of Medical Oncology, Beth Israel Deaconess Medical Center
- Celine M. Vachon
- Department of Health Science Research, Division of Epidemiology, Mayo Clinic
- Christi J. van Asperen
- Department of Clinical Genetics, Leiden University Medical Center
- Ans M. W. van den Ouweland
- Department of Clinical Genetics, Erasmus University Medical Center
- Elizabeth J. van Rensburg
- Department of Genetics, University of Pretoria
- Ana Vega
- Fundación Pública galega Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS
- Alessandra Viel
- Division of Functional onco-genomics and genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS
- Qin Wang
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Barbara Wappenschmidt
- Center for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Jeffrey N. Weitzel
- Clinical Cancer Genomics, City of Hope
- Camilla Wendt
- Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet
- Robert Winqvist
- Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu
- Xiaohong R. Yang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- Drakoulis Yannoukakos
- Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research ‘Demokritos’
- Argyrios Ziogas
- Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health
- Antonis C. Antoniou
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Roger L. Milne
- Cancer Epidemiology & Intelligence Division, Cancer Council Victoria
- Jonathan Beesley
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- Georgia Chenevix-Trench
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-018-08053-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Over 170 susceptibility loci have been identified by genome-wide association studies in breast cancer. Here, the authors interrogated the role of risk-associated variants from non-breast tissue, and using expression quantitative trait loci, identify potential target genes of known breast cancer susceptibility variants, as well as 11 regions not previously known to be associated with breast cancer risk.
