ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude

Huilin Li; Jiali Ou; Yaqun Li; Niannian Xu; Qing Li; Ping Wu; Chao Peng; Yun-Chi Tang; Hung-Chun Chang

doi:10.1038/s42003-022-03725-x

Communications Biology (Jul 2022)

ISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude

Huilin Li,
Jiali Ou,
Yaqun Li,
Niannian Xu,
Qing Li,
Ping Wu,
Chao Peng,
Yun-Chi Tang,
Hung-Chun Chang

Affiliations

Huilin Li: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Jiali Ou: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Yaqun Li: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Niannian Xu: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Qing Li: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Ping Wu: National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science
Chao Peng: National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai Advanced Research Institute, Chinese Academy of Science
Yun-Chi Tang: CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Hung-Chun Chang: Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s42003-022-03725-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Circadian modulators that exert amplitude-enhancing activity using highthroughput compound screening of small molecules identifies ISX-9, which is shown to augment CaMKIIδ expression, increasing BMAL1 activity via CaMKIIδ-dependent phosphorylation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal