Pleura and Peritoneum (Sep 2023)

UK trial of pressurised intraperitoneal aerosolised chemotherapy (PIPAC) with oxaliplatin for colorectal cancer peritoneal metastases (NCT03868228)

  • Kyle Peter,
  • Perry Kitrick,
  • Moutadjer Anne,
  • Gilfillan Nicholas,
  • Webb Rosalind,
  • Basak Dolan,
  • Ziprin Paul,
  • Blunt Dominic,
  • Burn James,
  • Van Ree Katherine,
  • Sergot Antoni,
  • Murphy Jamie

DOI
https://doi.org/10.1515/pp-2023-0008
Journal volume & issue
Vol. 8, no. 4
pp. 157 – 165

Abstract

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This is the first UK trial of pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for colorectal cancer peritoneal metastases. This trial aimed to assess the impact of PIPAC in combination with standard of care systemic treatment on: progression free survival (PFS); quality of life (QoL); and short-term complications. In addition, this trial set out to demonstrate that PIPAC can be performed safely in operating theatres within a National Health Service (NHS) setting.

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