JCRPE (Sep 2019)

Magnesium and Anti-phosphate Treatment with Bisphosphonates for Generalised Arterial Calcification of Infancy: A Case Report

  • Fatma Dursun,
  • Tülay Atasoy Öztürk,
  • Serçin Güven,
  • Heves Kırmızıbekmez,
  • Gülcan Seymen Karabulut,
  • Sevinç Kalın,
  • Betül Sözeri

DOI
https://doi.org/10.4274/jcrpe.galenos.2018.2018.0204
Journal volume & issue
Vol. 11, no. 3
pp. 311 – 318

Abstract

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Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries and resultant arterial stenosis. Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach. The case reported here was a patient with severe GACI diagnosed at three months of age who had no response to bisphosphonate treatment, but clinically improved after the initiation of magnesium and anti-phosphate (using calcium carbonate) treatments. In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.

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