Nature Communications (Jul 2021)

Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin

  • Anna V. Elleman,
  • Gabrielle Devienne,
  • Christopher D. Makinson,
  • Allison L. Haynes,
  • John R. Huguenard,
  • J. Du Bois

DOI
https://doi.org/10.1038/s41467-021-24392-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Photocaged molecules have advantages in terms of temporal and spatial control compared to conventional pharmacological compounds. The authors present a synthetic saxitoxin derivative affixed to a photocleavable group for precise modulation of Na channels.