Nature Communications (Oct 2018)

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

  • Lai Wen,
  • Susanne Feil,
  • Markus Wolters,
  • Martin Thunemann,
  • Frank Regler,
  • Kjestine Schmidt,
  • Andreas Friebe,
  • Marcus Olbrich,
  • Harald Langer,
  • Meinrad Gawaz,
  • Cor de Wit,
  • Robert Feil

DOI
https://doi.org/10.1038/s41467-018-06638-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al. develop a cGMP sensor mouse to follow cGMP dynamics in platelets, and find that shear stress activates NO-cGMP-cGKI signaling during platelet aggregation to limit thrombosis.