INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

Abstract

The Integrator complex (INT) is responsible for the 3′-end processing of several classes of non-coding RNAs. Here the authors show that the INTS10-INTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting.