Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

Camilo  G. Sotomayor; Isidor Minović; Manfred  L. Eggersdorfer; Ineke  J. Riphagen; Martin  H. de Borst; Louise  H. Dekker; Ilja  M. Nolte; Jan Frank; Sander  K.R. van Zon; Sijmen  A. Reijneveld; Jan  C. van der Molen; Michel  J. Vos; Jenny  E. Kootstra-Ros; Ramón Rodrigo; Ido  P. Kema; Gerjan  J. Navis; Stephan  J.L. Bakker

doi:10.3390/nu12020580

Nutrients (Feb 2020)

Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

Camilo G. Sotomayor,
Isidor Minović,
Manfred L. Eggersdorfer,
Ineke J. Riphagen,
Martin H. de Borst,
Louise H. Dekker,
Ilja M. Nolte,
Jan Frank,
Sander K.R. van Zon,
Sijmen A. Reijneveld,
Jan C. van der Molen,
Michel J. Vos,
Jenny E. Kootstra-Ros,
Ramón Rodrigo,
Ido P. Kema,
Gerjan J. Navis,
Stephan J.L. Bakker

Affiliations

Camilo G. Sotomayor: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Isidor Minović: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Manfred L. Eggersdorfer: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Ineke J. Riphagen: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Martin H. de Borst: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Louise H. Dekker: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Ilja M. Nolte: Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Jan Frank: Institute of Nutritional Sciences, University of Hohenheim, 70599 Stuttgart, Germany
Sander K.R. van Zon: Department of Health Sciences, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Sijmen A. Reijneveld: Department of Health Sciences, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Jan C. van der Molen: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Michel J. Vos: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Jenny E. Kootstra-Ros: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Ramón Rodrigo: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago CP 8380453, Chile
Ido P. Kema: Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Gerjan J. Navis: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Stephan J.L. Bakker: Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands

DOI: https://doi.org/10.3390/nu12020580
Journal volume & issue: Vol. 12, no. 2
p. 580

Abstract

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Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60−75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

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