A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome

Suhn Kyong Rhie; Andrew A. Perez; Fides D. Lay; Shannon Schreiner; Jiani Shi; Jenevieve Polin; Peggy J. Farnham

doi:10.1038/s41467-019-12079-8

Nature Communications (Sep 2019)

A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome

Suhn Kyong Rhie,
Andrew A. Perez,
Fides D. Lay,
Shannon Schreiner,
Jiani Shi,
Jenevieve Polin,
Peggy J. Farnham

Affiliations

Suhn Kyong Rhie: Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Andrew A. Perez: Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Fides D. Lay: Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Shannon Schreiner: Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Jiani Shi: Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Jenevieve Polin: Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
Peggy J. Farnham: Department of Biochemistry and Molecular Medicine and the Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/s41467-019-12079-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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In prostate cancer, chromatin structure can impact the transcriptome. Here, the authors develop high resolution chromatin interaction maps in prostate cancer cells using in situ Hi-C, revealing prostate cancer-specific TADs and enhancer-promoter loops surrounding the androgen receptor (AR) locus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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