Perfusion imaging of colorectal liver metastases treated with bevacizumab and stereotactic body radiotherapy

Jay S. Detsky; Laurent Milot; Yoo-Joung Ko; Pablo Munoz-Schuffenegger; William Chu; Gregory Czarnota; Hans T. Chung

Physics and Imaging in Radiation Oncology (Jan 2018)

Perfusion imaging of colorectal liver metastases treated with bevacizumab and stereotactic body radiotherapy

Jay S. Detsky,
Laurent Milot,
Yoo-Joung Ko,
Pablo Munoz-Schuffenegger,
William Chu,
Gregory Czarnota,
Hans T. Chung

Affiliations

Jay S. Detsky: Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
Laurent Milot: Department of Medical Imaging, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
Yoo-Joung Ko: Department of Medical Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medical Oncology, University of Toronto, Toronto, Ontario, Canada
Pablo Munoz-Schuffenegger: Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
William Chu: Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
Gregory Czarnota: Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Hans T. Chung: Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Corresponding author at: Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, T-wing, Toronto, Ontario M4N3M5, Canada.

Journal volume & issue: Vol. 5
pp. 9 – 12

Abstract

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Stereotactic body radiotherapy (SBRT) and bevacizumab are used in the treatment of colorectal liver metastases. This study prospectively evaluated changes in perfusion of liver metastases in seven patients treated with both bevacizumab and SBRT. Functional imaging using dynamic contrast-enhanced CT perfusion and contrast-enhanced ultrasound were performed at baseline, after bevacizumab, and after SBRT. After bevacizumab, a significant decrease was found in permeability (−28%, p < .05) and blood volume (−47%, p < .05), while SBRT led to a significant reduction in permeability (−22%, p < .05) and blood flow (−37%, p < .05). This study demonstrates that changes in perfusion can be detected after bevacizumab and SBRT. Keywords: Stereotactic body radiotherapy, Bevacizumab, Colorectal cancer, Liver metastases, CT perfusion

Published in Physics and Imaging in Radiation Oncology

ISSN: 2405-6316 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/physics-and-imaging-in-radiation-oncology/

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