Nature Communications (Sep 2021)

In vivo structure and dynamics of the SARS-CoV-2 RNA genome

  • Yan Zhang,
  • Kun Huang,
  • Dejian Xie,
  • Jian You Lau,
  • Wenlong Shen,
  • Ping Li,
  • Dong Wang,
  • Zhong Zou,
  • Shu Shi,
  • Hongguang Ren,
  • Youliang Wang,
  • Youzhi Mao,
  • Meilin Jin,
  • Grzegorz Kudla,
  • Zhihu Zhao

DOI
https://doi.org/10.1038/s41467-021-25999-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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RNA secondary structure is important for viral replication, transcription and translation. Here the authors employ SPLASH method and map in vivo RNA interactions and dynamics of SARS-CoV-2 RNA genome in different viral life cycles.