Nature Communications (May 2022)
Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling
- Hidenori Moriyama,
- Jin Endo,
- Masaharu Kataoka,
- Yuta Shimanaka,
- Nozomu Kono,
- Yuki Sugiura,
- Shinichi Goto,
- Hiroki Kitakata,
- Takahiro Hiraide,
- Naohiro Yoshida,
- Sarasa Isobe,
- Tsunehisa Yamamoto,
- Kohsuke Shirakawa,
- Atsushi Anzai,
- Yoshinori Katsumata,
- Makoto Suematsu,
- Kenjiro Kosaki,
- Keiichi Fukuda,
- Hiroyuki Arai,
- Motoaki Sano
Affiliations
- Hidenori Moriyama
- Department of Cardiology, Keio University School of Medicine
- Jin Endo
- Department of Cardiology, Keio University School of Medicine
- Masaharu Kataoka
- Department of Cardiology, Keio University School of Medicine
- Yuta Shimanaka
- Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Nozomu Kono
- Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Yuki Sugiura
- Department of Biochemistry, Keio University School of Medicine
- Shinichi Goto
- Department of Cardiology, Keio University School of Medicine
- Hiroki Kitakata
- Department of Cardiology, Keio University School of Medicine
- Takahiro Hiraide
- Department of Cardiology, Keio University School of Medicine
- Naohiro Yoshida
- Department of Cardiology, Keio University School of Medicine
- Sarasa Isobe
- Department of Cardiology, Keio University School of Medicine
- Tsunehisa Yamamoto
- Department of Cardiology, Keio University School of Medicine
- Kohsuke Shirakawa
- Department of Cardiology, Keio University School of Medicine
- Atsushi Anzai
- Department of Cardiology, Keio University School of Medicine
- Yoshinori Katsumata
- Department of Cardiology, Keio University School of Medicine
- Makoto Suematsu
- Department of Biochemistry, Keio University School of Medicine
- Kenjiro Kosaki
- Center for Medical Genetics, Keio University School of Medicine
- Keiichi Fukuda
- Department of Cardiology, Keio University School of Medicine
- Hiroyuki Arai
- Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Motoaki Sano
- Department of Cardiology, Keio University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-30621-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Pulmonary hypertension is a fatal disease that causes right heart failure due to pulmonary artery stenosis. Here, the authors find that ω-3 epoxides produced by the phospholipase PAF-AH2 in mast cells regulate pulmonary vascular remodeling.
