Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma

Justyna A. Resztak; Jane Choe; Shreya Nirmalan; Julong Wei; Julian Bruinsma; Russell Houpt; Adnan Alazizi; Henriette E. Mair-Meijers; Xiaoquan Wen; Richard B. Slatcher; Samuele Zilioli; Roger Pique-Regi; Francesca Luca

doi:10.1038/s41467-022-35742-z

Nature Communications (Jan 2023)

Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma

Justyna A. Resztak,
Jane Choe,
Shreya Nirmalan,
Julong Wei,
Julian Bruinsma,
Russell Houpt,
Adnan Alazizi,
Henriette E. Mair-Meijers,
Xiaoquan Wen,
Richard B. Slatcher,
Samuele Zilioli,
Roger Pique-Regi,
Francesca Luca

Affiliations

Justyna A. Resztak: Center for Molecular Medicine and Genetics, Wayne State University
Jane Choe: Center for Molecular Medicine and Genetics, Wayne State University
Shreya Nirmalan: Center for Molecular Medicine and Genetics, Wayne State University
Julong Wei: Center for Molecular Medicine and Genetics, Wayne State University
Julian Bruinsma: Department of Psychology, Wayne State University
Russell Houpt: Department of Psychology, Wayne State University
Adnan Alazizi: Center for Molecular Medicine and Genetics, Wayne State University
Henriette E. Mair-Meijers: Center for Molecular Medicine and Genetics, Wayne State University
Xiaoquan Wen: Department of Biostatistics, University of Michigan
Richard B. Slatcher: Department of Psychology, University of Georgia
Samuele Zilioli: Department of Psychology, Wayne State University
Roger Pique-Regi: Center for Molecular Medicine and Genetics, Wayne State University
Francesca Luca: Center for Molecular Medicine and Genetics, Wayne State University

DOI: https://doi.org/10.1038/s41467-022-35742-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

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Puberty is an important developmental period marked by hormonal, metabolic and immunological changes. Here the authors report gene expression changes in immune cells associated with age and puberty, and that may be relevant for sex differences in susceptibility to asthma, in a longitudinal cohort of 251 children with asthma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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