Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy

Alex W. Wessel; Nurgun Kose; Robin G. Bombardi; Vicky Roy; Warangkana Chantima; Juthathip Mongkolsapaya; Melissa A. Edeling; Christopher A. Nelson; Irene Bosch; Galit Alter; Gavin R. Screaton; David H. Fremont; James E. Crowe; Michael S. Diamond

doi:10.1038/s41467-020-19096-y

Nature Communications (Oct 2020)

Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy

Alex W. Wessel,
Nurgun Kose,
Robin G. Bombardi,
Vicky Roy,
Warangkana Chantima,
Juthathip Mongkolsapaya,
Melissa A. Edeling,
Christopher A. Nelson,
Irene Bosch,
Galit Alter,
Gavin R. Screaton,
David H. Fremont,
James E. Crowe,
Michael S. Diamond

Affiliations

Alex W. Wessel: Department of Pathology and Immunology, Washington University School of Medicine
Nurgun Kose: Departments of Pediatrics, Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
Robin G. Bombardi: Vanderbilt Vaccine Center, Vanderbilt University Medical Center
Vicky Roy: Ragon Institute of MGH, MIT, and Harvard University
Warangkana Chantima: Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford
Juthathip Mongkolsapaya: Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford
Melissa A. Edeling: Department of Pathology and Immunology, Washington University School of Medicine
Christopher A. Nelson: Department of Pathology and Immunology, Washington University School of Medicine
Irene Bosch: E25Bio, Inc., The Engine of MIT
Galit Alter: Ragon Institute of MGH, MIT, and Harvard University
Gavin R. Screaton: Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford
David H. Fremont: Department of Pathology and Immunology, Washington University School of Medicine
James E. Crowe: Departments of Pediatrics, Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
Michael S. Diamond: Department of Pathology and Immunology, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-19096-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Zika virus is an arthropod-transmitted flavivirus that can cause microcephaly and other fetal abnormalities during pregnancy. Here Wessel et al. develop antibodies against the Zika virus nonstructural protein 1 that protect non-pregnant and pregnant mice against infection, and define particular antibody epitopes and mechanisms underlying this protection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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